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| CAS-Nr. | 50-07-7 |
| Bezeichnung: | 6-Amino-8-(((aminocarbonyl)oxy)-methyl)-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino-(2',3': 3,4)pyrrolo(1,2-a)indol-4,7-dion,(1aS-(1a alpha, 8 beta, 8a alpha,8b alpha))- |
| Englisch Name: | Mitomycin C |
| Synonyma: | Mitomycin;6-Amino-8-(((aminocarbonyl)oxy)-methyl)-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino-(2',3': 3,4)pyrrolo(1,2-a)indol-4,7-dion,(1aS-(1a alpha, 8 beta, 8a alpha,8b alpha))-
MMC;Mitonco;nsc26980;AMETYCIN;Mitoplus;MitoMyci;ametycine;mytomycin;nsc-26980;MITOCIN C |
| CBNumber: | CB8456544 |
| Summenformel: | C15H18N4O5 |
| Molgewicht: | 334.33 |
| MOL-Datei: | 50-07-7.mol |
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| 6-Amino-8-(((aminocarbonyl)oxy)-methyl)-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino-(2',3': 3,4)pyrrolo(1,2-a)indol-4,7-dion,(1aS-(1a alpha, 8 beta, 8a alpha,8b alpha))- physikalisch-chemischer Eigenschaften |
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| solubility : |
H2O: 4 mL/vial Stock solutions should be filter sterilized and stored at 2-8 °C in the dark., clear to slightly hazy, blue to purple
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| Wasserlöslichkeit: |
soluble |
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| Stabilität:: |
Stable. Incompatible with strong acids, strong bases, strong oxidizing agents. |
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| EPA chemische Informationen: |
Azirino[2', 3':3,4]pyrrolo[1,2-a] indole-4,7-dione, 6-amino-8-[[(aminocarbonyl) oxy]methyl]-1,1a,2,8,8a,8b- hexahydro-8a-methoxy-5-methyl-, (1aS,8S,8aR,8bS)-(50-07-7) |
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6-Amino-8-(((aminocarbonyl)oxy)-methyl)-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino-(2',3': 3,4)pyrrolo(1,2-a)indol-4,7-dion,(1aS-(1a alpha, 8 beta, 8a alpha,8b alpha))- Chemische Eigenschaften,Einsatz,Produktion Methoden |
Chemische Eigenschaften
Blue-Violet Crystals |
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Verwenden
An antitumor antibiotic. It is used as antineoplastic. |
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Verwenden
Mitomycin C is the most studied of a family of highly distinctive blue/purple metabolites produced by several Streptomyces species. Mitomyin C exhibits potent antibacterial and antitumour activity and inhibits DNA synthesis by intercalation, blocking nuclear division with the induction of apoptosis in cancer cells. |
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Verwenden
Mitomycin C is the most studied of a family of highly distinctive blue/purple metabolites produced by several Streptomyces species. Mitomycin C exhibits potent antibacterial and antitumor activity and inhibits DNA synthesis by intercalation, blocking nuclear division with the induction of apoptosis in cancer cells. |
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Allgemeine Beschreibung
Blue-violet crystals. Used as an anti-tumor antibiotic complex. |
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Air & Water Reaktionen
Water soluble. |
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Reaktivität anzeigen
Mitomycin C is sensitive to prolonged exposure to light. Mitomycin C may be sensitive to prolonged exposure to air. Mitomycin C is incompatible with strong oxidizing agents, strong acids and strong bases. Calcium salts may cause decomposition. |
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Health Hazard
Toxic doses as low as 750 mg/kg have been reported in humans. The major toxic effect is myelosuppression, characterized by marked leukopenia and thrombocytopenia; this may be delayed and cumulative. Interstitial pneumonia and glomerular damage resulting in kidney failure are unusual but well documented complications. Lung conditions -- administration of mitomycin has been recognized as causing pneumonitis, alveolitis and pulmonary fibrosis. Kidney conditions -- administration of Mitomycin Can cause kidney damage. Kidney toxicity was observed in 1-5 percent of patients. Depressed immune conditions. |
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Brandgefahr
Flash point data for Mitomycin C are not available; however, Mitomycin C is probably combustible. |
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R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.
R22:Gesundheitsschädlich beim Verschlucken.
R45:Kann Krebs erzeugen.
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut. |
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S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S22:Staub nicht einatmen. |
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Biologische Aktivit?t
Antibiotic and antitumor agent. Covalently binds DNA forming intra- and interstrand crosslinks. Inhibits DNA synthesis. |
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| 6-Amino-8-(((aminocarbonyl)oxy)-methyl)-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino-(2',3': 3,4)pyrrolo(1,2-a)indol-4,7-dion,(1aS-(1a alpha, 8 beta, 8a alpha,8b alpha))- Upstream-Materialien And Downstream Produkte |
Upstream-Materialien
Dichlormethan
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Downstream Produkte
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| 6-Amino-8-(((aminocarbonyl)oxy)-methyl)-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino-(2',3': 3,4)pyrrolo(1,2-a)indol-4,7-dion,(1aS-(1a alpha, 8 beta, 8a alpha,8b alpha))- Anbieter Lieferant Produzent Hersteller Vertrieb Händler. Global( 193)Lieferanten |
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)methyl)-1,1a,2,8,8a,8b-hexahydro-8-a-methoxy-5-methyl-,(1as-(1aalpha,8beta,
7-amino-9-alpha-methoxymitosane
8aalpha,8balpha))-(9ci)
8balpha)]-8aalph
ametycine
azirino(2’,3’:3,4)pyrrolo(1,2-a)indole-4,7-dione,6-amino-1,1a,2,8,8a,8b-hexahy
azirino(2’,3’:3,4)pyrrolo(1,2-a)indole-4,7-dione,6-amino-8-(((aminocarbonyl)oxy
azirino[2’,3’:3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)ox
mitomycinum
mitomycynac
mitomycynac(polish)
mytomycin
nci-c04706
nsc26980
nsc-26980
rcrawastenumberu010
y]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-,[1as-(1aalpha,8beta,
50-07-7
6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione carbamate (ester)
AMETYCIN
Antibiotics A to Z
Antibiotics G-M
Antibiotics
BioChemical
[1ar-(1aalpha,8beta,8aalpha,8balpha)]-6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-alpha]indole-4,7-dione
MITOCIN C
MITOMYCIN
MITOMYCIN C
MITOMYCIN C, STREPTOMYCES CAESPITOSUS
MMC
MUTAMYCIN
mitomycin C from streptomyces*caespitosus
MITOMYCIN C, VIAL WITH 2 MG*
MITOMYCIN C FROM STREPTOMYCES*CAESPITOSU S CELL CULT
MitomycinCuSp28
MitomycinC,4%inNaCl
MitomycinC/NaCl
MITOMYCIN A
Mitomycin C, contains 2 mg Mitomycin C and 48 mg NaCl
C15H18N4O5
1950-07-7
Mitomycin C, carrier-free
Azirino2,3:3,4pyrrolo1,2-aindole-4,7-dione, 6-amino-8-(aminocarbonyl)oxymethyl-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, (1aS,8S,8aR,8bS)-
MITOMYCIN,USP
Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-5-methyl-, carbamate (ester) (8CI)
Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, (1aS,8S,8aR,8bS)- (9CI)
Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, [1aS-(1aa,8b,8aa,8ba)]-
MitoExtra
Mitonco
Mitoplus
MITOMICYNC
Mitoycin C
Azirino[2’,3’:3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-[1aS-(1aalpha,8beta,8aalpha,8balpha)]-
1950-07-7
Antibiotics
[1aR-(1aalpha,8beta,8aalpha,8balpha)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-alpha]indole-4,7-dione
6-Amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione carbamate (ester)
MITOMYCIN C (2MG) IN 48MG SODIUM CHLORIDE
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