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| CAS No. | 2001-95-8 |
| Chemical Name: | VALINOMYCIN |
| Synonyms: | nsc122023;-valyl)[qr];valinomicin;VALINOMYCIN;nsc122023[qr];valinomicin[qr];VALINOMYCIN 99%;Valinomycin,90%;Valinomycin,96%;antibioticn-329b |
| CBNumber: | CB7199194 |
| Molecular Formula: | C54H90N6O18 |
| Formula Weight: | 1111.32 |
| MOL File: | 2001-95-8.mol |
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| VALINOMYCIN Property |
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| solubility : |
DMSO: ≥10 mg/mL
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VALINOMYCIN Chemical Properties,Usage,Production |
Chemical Properties
white crystalline powder |
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Usage
antibiotic; LD50 (rat, po) 4 mg/kg |
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Usage
K+-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and anta
gonizes ET-induced vasoconstriction. Used as insecticide, nematocide. |
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Usage
Valinomycin is a hydrophobic cyclodepsipeptide with potent antitumour activity. Valinomycin is a highly selective potassium ionophore and this action leads to a diverse range of profound cell membrane effects. More recently, valinomycin has found application as a biosensor to detect to detect potassium efflux. |
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Usage
Valinomycin is a hydrophobic cyclodepsipeptide with potent antitumor activity. Valinomycin is a highly selective potassium ionophore and this action leads to a diverse range of profound cell membrane effects. More recently, valinomycin has found application as a biosensor to detect to detect potassium efflux. |
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General Description
Shiny crystalline solid. Used as an insecticide and nematocide. Not registered as a pesticide in the U.S. |
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Reactivity Profile
VALINOMYCIN is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). |
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Health Hazard
VALINOMYCIN is highly toxic orally. |
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Fire Hazard
When heated to decomposition, VALINOMYCIN emits toxic fumes of nitrogen oxides. |
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Biological Activity
Selective K + ionophore (K 0.5 values are 48, 73, 75, 93 and 246 mM for K + , Rb + , Cs + , Na + and Li + respectively) that transports K + across biological and artificial lipid membranes. Inhibits Ca 2+ -ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro . |
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| VALINOMYCIN Preparation Products And Raw materials |
Raw materials
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Preparation Products
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| VALINOMYCIN Suppliers Global( 72)Suppliers |
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1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11,
14,17,20,23,26,29,32,35-dodecone,12,24,36-trimetyl-3,6,9,15,18,21,27,30,33-non
akis(1-methylethyl)-[qr]
aleryl-d-valyl-l-lactoyl-l-valyl-d-alpha-hydroxyisovaleryl-d-valyl-l-lactoyl-l
antibioticn-329b
cyclic(d-alpha-hydroxyisovaleryl-d-valyl-l-lactoyl-l-valyl-d-alpha-hydroxyisov
nsc122023
nsc122023[qr]
valinomicin
valinomicin[qr]
-valyl)[qr]
VALINOMYCIN
VALINOMYCIN, STREPTOMYCES FULVISSIMUS
Ionophores Potentiometric for ISE
Ion Sensor Materials
POTASSIUM IONOPHORE I
BioChemical
Analytical Chromatography Product Catalog
Antibiotics A to Z
Antibiotics
Antibiotics T-Z
2001-95-8
CYCLO[-L-VAL-D-HYLVA-D-VAL-L-LAC-]3
CYCLO(LAC-VAL-D-HIV-D-VAL-LAC-VAL-D-HIV-D-VAL-)
Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)3: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid
VALINOMYCIN >94% PURITY
VALINOMYCIN READY MADE SOLUTION
VALINOMYCIN 99%
C54H90N6O18
VALINOMYCIN,CRYSTAL
Valinomycin,90%
Valinomycin,96%
Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)
VALINOMYCINRESEARCH GRADE
Potassium ionophore I,Valinomycin
Valinomycin,Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)3: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid
Agro-Products
Inhibitors
Peptides
1Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-
hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)
3,6,9,15,18,21,27,30,33-Nonaisopropyl-12,24,36-triMethyl-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone
antibiotic
ValinoMycin, froM StreptoMyces fulvissiMus
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