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| CAS番号. | 292632-98-5 |
| 化学名: | |
| 别名: | |
| 英語化学名: | L-685 458 |
| 英語别名: | (5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucy-L-phenylalaninamide;N-[(2R,4R,5S)-5-[[(1,1-DiMethylethoxy)carbonyl]aMino]-4-hydroxy-1-oxo-6- phenyl-2-(phenylMethyl)hexyl]-L-leucyl-L-phenylalaninaMide |
| CBNumber: | CB1503740 |
| 分子式: | C39H52N4O6 |
| 分子量: | 672.862 |
| MOL File: | 292632-98-5.mol |
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| L-685 458 物理性質 |
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| solubility : |
DMSO: >10 mg/mL, soluble
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L-685 458 化学特性,用途語,生産方法 |
生物活性
Potent and selective γ -secretase inhibitor (IC 50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of A β 40 and A β 42 peptides (IC 50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro . |
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| L-685 458 上流と下流の製品情報 |
原材料
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準備製品
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| L-685 458 生産企業 Global( 11)Suppliers |
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