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| CAS番号. | 909910-43-6 |
| 化学名: | |
| 别名: | |
| 英語化学名: | A-83-01 |
| 英語别名: | 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide |
| CBNumber: | CB9972670 |
| 分子式: | C25H19N5S |
| 分子量: | 421.526 |
| MOL File: | 909910-43-6.mol |
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A-83-01 化学特性,用途語,生産方法 |
使用
A 83-01 is a selective inhibitor of TGF-β type I receptor. A 83-01 treatment increases tumor permeability. |
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生物活性
Selective inhibitor of TGF- β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC 50 values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF- β -induced epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. More potent than SB 431542 (4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol -2-yl]benzamide). Inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. Helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs. |
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| A-83-01 上流と下流の製品情報 |
原材料
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準備製品
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| A-83-01 生産企業 Global( 22)Suppliers |
| 名前 | 電話番号 | ファックス番号 | 電子メール | 国籍 | 製品カタログ | 優位度 |
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J & K SCIENTIFIC LTD.
| -- | -- | jkinfo@jkchemical.com;market3@jkchemical.com | CHINA |
96847
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76
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3B Pharmachem (Wuhan) International Co.,Ltd.
| 86-21-50328103 * 801、802、803、804 Mobile:18930552037 | 86-21-50328109 | 67055399@qq.com | CHINA |
15983
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69
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BOC Sciences
| 1-631-504-6093 | 1-631-614-7828 | sales@bocsci.com | USA |
9972
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65
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Dalian Meilun Biotech Co., Ltd.
| 0411-66771943；0411-66771942 | 0411-66771945 | sales@meilune.com | CHINA |
5010
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58
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T&W GROUP
| +86-21-61551611, 61551413, 61551420, 61551610 | +86-21-50676805 | contact@trustwe.com | CHINA |
13395
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58
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Shanghai Haoyuan Chemexpress Co., Ltd
| 86-21-58998590 | 86-21-53700326, 86-21-58998590 | sales@chemexpress.cn | CHINA |
10011
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61
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MedChemexpress LLC
| 609-228-6898 | 609-228-5909 | sales@medchemexpress.cn | USA |
4935
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58
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Zhengzhou HSH Science & Technology Co., Ltd.
| 18937192232;0371-55932928 | 0086-0371-55932928 | 1282296214@qq.com | CHINA |
453
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55
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AdooQ BioScience, LLC
| +1 (866) 930-6790 | +1 (866) 333-9607 | info@adooq.com | USA |
2786
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58
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Shanghai TaoSu Biochemical Technology Co., Ltd.
| 021-33632979 | 021-33632979 | info@tsbiochem.com | CHINA |
3112
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58
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