| 公司名称： |
上海波以尔化工有限公司 |
| 联系电话： |
Mr Qiu 86-21-50182298(Domestic Market)Miss Xu 86-21-50180596(Abroad Market) |
| 产品介绍： |
中文名称:4-氟-N-甲基-N-[1-[4-(1-甲基-1H-吡唑-5-基)-1-酞嗪基]-4-哌啶基]-2-(三氟甲基)苯甲酰胺
英文名称:LY2940680
CAS:1258861-20-9
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| 公司名称： |
上海佰世凯化学科技有限公司 |
| 联系电话： |
+86(0)21-20908456 |
| 产品介绍： |
英文名称:LY 2940680
CAS:1258861-20-9
备注：C13843 |
| 公司名称： |
济南精合医药科技有限公司 |
| 联系电话： |
+86 (531) 88811793；+86 (531) 88811783;+(0)18854807083; |
| 产品介绍： |
英文名称:LY2940680
CAS:1258861-20-9
纯度：99% 包装信息：5Mg, 10Mg, 20Mg, 50Mg |
| 公司名称： |
ShangHai Biochempartner Co.,Ltd |
| 联系电话： |
+86 13818785766，400-021-9906 |
| 产品介绍： |
英文名称:LY2940680
CAS:1258861-20-9
纯度：>98% .NMR+LCMS 包装信息：50Mg/100Mg/500Mg/1g/5g/10g/ |
| 公司名称： |
BOC Sciences |
| 联系电话： |
1-631-504-6093 |
| 产品介绍： |
英文名称:LY2940680
CAS:1258861-20-9
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| 中文名称: | Taladegib (LY2940680) | | 中文同义词: | 4-氟-N-甲基-N-[1-[4-(1-甲基-1H-吡唑-5-基)-1-酞嗪基]-4-哌啶基]-2-(三氟甲基)苯甲酰胺;4-氟-N-甲基-N-[1-[4-(1-甲基-1H-吡唑-5-基)-1-酞嗪基]-4-哌啶基]-2-(三氟甲基)苯甲酰胺(LY2940680) | | 英文名称: | Taladegib (LY2940680) | | 英文同义词: | LY2940680;4-Fluoro-N-methyl-N-[1-[4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl]-4-piperidinyl]-2-(trifluoromethyl)benzamide;4-fluoro-N-Methyl-N-(1-(4-(1-Methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoroMethyl)benzaMide;4-fluoro-N-Methyl-N-[1-[4-(2-Methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-2-(trifluoroMethyl)benzaMide;Taladegib (LY2940680);4-Fluoro-N-methyl-N-[1-[4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl]-4-piperidinyl]-2-(trifluoromethyl)benzamide LY 2940680 | | CAS号: | 1258861-20-9 | | 分子式: | C26H24F4N6O | | 分子量: | 0 | | EINECS号: | | | 相关类别: | 信号转导通路激酶抑制剂;干细胞与Wnt信号;活性分子;抑制剂 |
| 生物活性 | Taladegib (LY2940680)与Smoothened(Smo)受体结合，有效抑制Hedgehog(Hh)信号通路。Phase 1/2。 | | 体外研究 | LY2940680 inhibits cancer growth in cell lines containing a mutation in the gene encoding Smoothened that researchers had previously observed in patient with cancer who developed resistance to vismodegib. | | 体内研究 | LY2940680 has excellent pharmacokinetic properties in rodent and non-rodent species. LY2940680 administrated orally treats Ptch+/- p53-/- transgenic mice which spontaneously develop medulloblastoma, produces remarkable efficacy and significantly improves their survival. LY2940680 reveals rapid kinetics of anti-tumor activity through magnetic resonance imaging of these mice, and LY2940680 induces Caspase-3 activity and reduces proliferation by immunohistochemistry analysis of medulloblastoma tumors. LY2940680 inhibits Hh regulated gene expression in the subcutaneous xenograft tumor stroma and produces significant anti-tumor activity. |
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