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Genistein

Genistein Suppliers list
Company Name:Shanghai Tauto Biotech Co., Ltd  Gold
Tel:0086-21-51320588
Email:export2@tautobiotech.com
Products Intro: Product Name:Genistein
CAS:446-72-0
Purity:NLT 95% HPLC Package:10Mg;20Mg;50Mg;100Mg to graMs.Not More than tens of graMs. Remarks:E-0005
Company Name:J & K SCIENTIFIC LTD.  
Tel:400-666-7788 +86-10-82848833
Email:jkinfo@jkchemical.com;market3@jkchemical.com
Products Intro: Product Name:Genistein
CAS:446-72-0
Purity:99% Package:100MG,10MG,1G,25MG
Company Name:Meryer (Shanghai) Chemical Technology Co., Ltd.  
Tel:+86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-59487313(Beijing)
Email:sh@meryer.com
Products Intro: Product Name:Genistein
CAS:446-72-0
Purity:>96.0%(LC) Package:100Mg;1g Remarks:G0272
Company Name:INTATRADE GmbH  
Tel:+49 3493/605464
Email:sales@intatrade.de
Products Intro: Product Name:Genistein Synonyms 4',5,7-Trihydroxyisoflavone
CAS:446-72-0
Remarks:NN04365
Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel:86-21-50328103 * 801、802、803、804 Mobile:18930552037
Email:67055399@qq.com
Products Intro: Product Name:Genistein;5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CAS:446-72-0
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Genistein Basic information
Product Name:Genistein
Synonyms:4’,5,7-trihydroxy-isoflavon;5,7-dihydroxy-3-(4-hydroxyphenyl)-4h-1-benzopyran-4-on;c.i.75610;differenola;genistein(synthetic);genisteol;genisterin;prunetol
CAS:446-72-0
MF:C15H10O5
MW:270.24
EINECS:207-174-9
Product Categories:pharmacetical;Biochemistry;Flavonoids;Natural Plant Extract;The group of Daidzin;Inhibitors;Tyrosine Kinase Inhibitors;Protein Kinase;Signalling;Plant extract;Herb extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;inhibitor
Mol File:446-72-0.mol
Genistein Structure
Genistein Chemical Properties
mp 297-298 °C
storage temp. −20°C
solubility DMSO: soluble
form powder
color off-white
Water Solubility insoluble
Merck 14,4391
BRN 263823
Stability:Light Sensitive
CAS DataBase Reference446-72-0(CAS DataBase Reference)
EPA Substance Registry System4H-1-Benzopyran- 4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)- (446-72-0)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/38-22
Safety Statements 26-24/25-22
WGK Germany 3
RTECS NR2392000
HazardClass IRRITANT
Hazardous Substances Data446-72-0(Hazardous Substances Data)
MSDS Information
ProviderLanguage
Genistein English
SigmaAldrich English
ACROS English
ALFA English
Genistein Usage And Synthesis
Chemical PropertiesYellow Crystalline Solid
UsageExhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol
UsageGenistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.
Usagecytotoxic inhibitor of tyrosine kinase and topoisomerase II kinase
Biological ActivityPhytoestrogen with a wide range of biological actions. Inhibits protein tyrosine kinases including epidermal growth factor receptor kinase. Also binds to PPAR γ and estrogen receptors and acts as an agonist at GPR30. Also available as part of the MAPK Cascade Inhibitor Tocriset™ .
Genistein Preparation Products And Raw materials
Raw materialsDiethyl ether
Tag:Genistein(446-72-0) Related Product Information
Puerarin Quercetin dihydrate HESPERETIN Genistein 4′-methyl ether 2-CARBETHOXY-5,7-DIHYDROXY-4'-METHOXYISOFLAVONE Prunetin Genistein-7-O-β-D-glucopyranoside ,Genistein-7-b-O-Glucopyranoside,Genistein-7--O-Glucopyranoside,4μ,5,7-Trihydroxyisoflavone 7-glucoside, Genistein 7-glucoside, Genistein-7-O-β-D-glucopyranoside,GENISTEIN, 7-O-BETA-D-GLUCOPYRANOSIDE,GENISTEIN-7-GLUCOSIDE,GENISTEIN-7-O-GLUCOSIDE,GLUCOSYL-7-GENISTEIN,genistein,7-beta-d-glucopyranosid ISOPOMIFERIN-3',4'-DIMETHYL ETHER Hematoxylin DIOSMETIN LIGNINE REACTIVE DYES DISPERSE DYE Direct Dyes ACID DYES Chrysin 7-HYDROXYISOFLAVONE ISOFLAVONES