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Doxycycline(564-25-0)

Doxycycline(564-25-0)
Product IdentificationBack to Contents
【Product Name】

Doxycycline
【Synonyms】

(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
6-Deoxy-5-hydroxytetracycline
6-Deoxytetracycline
alpha-6-Deoxy-5-hydroxytetracycline
alpha-6-Deoxyoxytetracycline
Doxycyclin hyclate
【CAS】

564-25-0
【Formula】

C22H24N2O8
【Molecular Weight】

444.44
【EINECS】

209-271-1
【RTECS】

QI8650000
【RTECS Class】

Drug; Mutagen; Reproductive Effector; Human Data
【Merck】

12,3496
【Beilstein/Gmelin】

2230419
Physical and Chemical PropertiesBack to Contents
【Appearance】

Yellow, crystalline powder with slight ethanolic odor.
【Solubility in water】

Slightly soluble
【Vapor Pressure】

2E-24 (25 C)
【pKa/pKb】

4.50 (pKa)
【Partition Coefficient】

-.26
【Usage】

Medication.
First Aid MeasuresBack to Contents
【Ingestion】

Flush mouth out with water. Seek medical attention.
【Inhalation】

Remove to fresh air.
【Skin】

Flush with copious amounts of water for at least 15 minutes.
【Eyes】

Flush with copious amounts of water for at least 15 minutes.
Handling and StorageBack to Contents
【Storage】

store in a tightly closed container.
【Handling】

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Hazards IdentificationBack to Contents
【Inhalation】

Allergic reaction. Irritation.
【Skin】

Skin hyperpigmentation has been reported.
【Eyes】

Irritation.
【Ingestion】

Nausea, vomiting, epigastric burning, and abdominal discomfort have been noted. Tetracycline and doxycycline have been implicated in causing esophageal ulceration, but this is thought to be uncommon.
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Rubber or vinyl gloves, safety goggles and appropriate laboratory clothings.
【Respirators】

NIOSH approved respirator.
【Exposure Effects】

Headache, papilledema and benign intracranial hypertension have been reported. Maternal ingestion of tetracyclines during pregnancy may cause tooth discoloration, enamel defects, and other congenital anomalies. <br>Hepatotoxicity, pancreatitis, and renal failure may occur in pregnant women following ingestion of tetracyclines during pregnancy.
Fire Fighting MeasuresBack to Contents
【Fire Fighting】

Evacuate area. Wear SCBA and protective clothing. Use agent most suitable for extinguishing surrounding fire.
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Wear dust respirator and rubber gloves. Sweep up, avoiding dust generation. Place in appropriate container for disposal.
Stability and ReactivityBack to Contents
【Stability】

Stable at normal temperatures and pressures.
【Decomposition】

Toxic fumes.
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