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| CAS-Nr. | 2001-95-8 |
| Bezeichnung: | Valinomycin |
| Englisch Name: | VALINOMYCIN |
| Synonyma: | Valinomycin
nsc122023;-valyl)[qr];valinomicin;VALINOMYCIN;nsc122023[qr];valinomicin[qr];VALINOMYCIN 99%;Valinomycin,90%;Valinomycin,96%;antibioticn-329b |
| CBNumber: | CB7199194 |
| Summenformel: | C54H90N6O18 |
| Molgewicht: | 1111.32 |
| MOL-Datei: | 2001-95-8.mol |
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| Valinomycin physikalisch-chemischer Eigenschaften |
| Schmelzpunkt:: |
186-190 °C
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| solubility : |
DMSO: ≥10 mg/mL
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Valinomycin Chemische Eigenschaften,Einsatz,Produktion Methoden |
Chemische Eigenschaften
white crystalline powder |
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Verwenden
antibiotic; LD50 (rat, po) 4 mg/kg |
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Verwenden
K+-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and anta
gonizes ET-induced vasoconstriction. Used as insecticide, nematocide. |
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Verwenden
Valinomycin is a hydrophobic cyclodepsipeptide with potent antitumour activity. Valinomycin is a highly selective potassium ionophore and this action leads to a diverse range of profound cell membrane effects. More recently, valinomycin has found application as a biosensor to detect to detect potassium efflux. |
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Verwenden
Valinomycin is a hydrophobic cyclodepsipeptide with potent antitumor activity. Valinomycin is a highly selective potassium ionophore and this action leads to a diverse range of profound cell membrane effects. More recently, valinomycin has found application as a biosensor to detect to detect potassium efflux. |
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Allgemeine Beschreibung
Shiny crystalline solid. Used as an insecticide and nematocide. Not registered as a pesticide in the U.S. |
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Reaktivität anzeigen
VALINOMYCIN is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). |
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Health Hazard
VALINOMYCIN is highly toxic orally. |
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Brandgefahr
When heated to decomposition, VALINOMYCIN emits toxic fumes of nitrogen oxides. |
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R-Sätze Betriebsanweisung:
R27/28:Sehr giftig bei Berührung mit der Haut und beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut. |
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S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren. |
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Biologische Aktivit?t
Selective K + ionophore (K 0.5 values are 48, 73, 75, 93 and 246 mM for K + , Rb + , Cs + , Na + and Li + respectively) that transports K + across biological and artificial lipid membranes. Inhibits Ca 2+ -ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro . |
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| Valinomycin Upstream-Materialien And Downstream Produkte |
Upstream-Materialien
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Downstream Produkte
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| Valinomycin Anbieter Lieferant Produzent Hersteller Vertrieb Händler. Global( 72)Lieferanten |
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1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11,
14,17,20,23,26,29,32,35-dodecone,12,24,36-trimetyl-3,6,9,15,18,21,27,30,33-non
akis(1-methylethyl)-[qr]
aleryl-d-valyl-l-lactoyl-l-valyl-d-alpha-hydroxyisovaleryl-d-valyl-l-lactoyl-l
antibioticn-329b
cyclic(d-alpha-hydroxyisovaleryl-d-valyl-l-lactoyl-l-valyl-d-alpha-hydroxyisov
nsc122023
nsc122023[qr]
valinomicin
valinomicin[qr]
-valyl)[qr]
VALINOMYCIN
VALINOMYCIN, STREPTOMYCES FULVISSIMUS
Ionophores Potentiometric for ISE
Ion Sensor Materials
POTASSIUM IONOPHORE I
BioChemical
Analytical Chromatography Product Catalog
Antibiotics A to Z
Antibiotics
Antibiotics T-Z
2001-95-8
CYCLO[-L-VAL-D-HYLVA-D-VAL-L-LAC-]3
CYCLO(LAC-VAL-D-HIV-D-VAL-LAC-VAL-D-HIV-D-VAL-)
Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)3: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid
VALINOMYCIN >94% PURITY
VALINOMYCIN READY MADE SOLUTION
VALINOMYCIN 99%
C54H90N6O18
VALINOMYCIN,CRYSTAL
Valinomycin,90%
Valinomycin,96%
Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)
VALINOMYCINRESEARCH GRADE
Potassium ionophore I,Valinomycin
Valinomycin,Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)3: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid
Agro-Products
Inhibitors
Peptides
1Cyclo(D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-
hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-α-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)
3,6,9,15,18,21,27,30,33-Nonaisopropyl-12,24,36-triMethyl-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone
antibiotic
ValinoMycin, froM StreptoMyces fulvissiMus
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