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| CAS-Nr. | 51-21-8 |
| Bezeichnung: | Fluoruracil |
| Englisch Name: | 5-Fluorouracil |
| Synonyma: | Fluoruracil
FU;Ulup;5-FU;Fluri;Arumel;Efudex;Efudix;Efurix;Fluril;U-8953 |
| CBNumber: | CB8162744 |
| Summenformel: | C4H3FN2O2 |
| Molgewicht: | 130.08 |
| MOL-Datei: | 51-21-8.mol |
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| Fluoruracil physikalisch-chemischer Eigenschaften |
| Schmelzpunkt:: |
282-286 °C (dec.)(lit.)
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| Siedepunkt:: |
190-200°C/0.1mmHg |
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| storage temp. : |
Store at 0-5 |
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| solubility : |
H2O: 10 mg/mL, clear
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| Wasserlöslichkeit: |
12.2 g/L 20 ºC |
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| Sensitive : |
Air Sensitive |
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| Stabilität:: |
Stable. Light sensitive. Combustible. Incompatible with strong oxidizing agents, strong bases. |
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Fluoruracil Chemische Eigenschaften,Einsatz,Produktion Methoden |
Chemische Eigenschaften
Crystalline |
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Verwenden
A potent antineoplastic agent in clinical use. Also an inhibitor of DNA synthesis |
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Verwenden
antineoplastic, pyrimidine antimetabolite |
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Verwenden
5-Fluoro Uracil is an active metabolite of Doxifluridine (D556750). |
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Allgemeine Beschreibung
White to nearly white crystalline powder; practically odorless. Used as an anti neoplastic drug, chemosterilant for insects. |
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Air & Water Reaktionen
Insoluble in water. |
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Reaktivität anzeigen
5-Fluorouracil may be sensitive to prolonged exposure to light. Solutions discolor on storage. 5-Fluorouracil can react with oxidizing agents and strong bases. Incompatible with methotrexate sodium. |
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Health Hazard
Minimum toxic dose in humans is approximately 450 mg/kg (total dose) over 30 days for the ingested drug. Intravenous minimum toxic dose in humans is a total dose of 6 mg/kg over three days. Depression of white blood cells occurred after intravenous administrative of a total dose of 480 mg/kg over 32 days. Occasional neuropathy and cardiac toxicity have been reported. Do not use during pregnancy. Patients with impaired hepatic or renal function, with a history of high-dose pelvic irradiation or previous use of alkylating agents should be treated with extreme caution. Patients with nutritional deficiencies and protein depletion have a reduced tolerance to 5-Fluorouracil. |
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Brandgefahr
Emits very toxic fumes of flourides and nitrogen oxides when heated to decomposition. Avoid decomposing heat. |
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R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut. |
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S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen. |
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Biologische Aktivit?t
Anticancer agent. Metabolized to form fluorodeoxyuridine monophosphate (FdUMP), fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine (FUTP). FdUMP inhibits thymidylate reductase causing a reduction in dTMP synthesis. FUTP and FdUTP are misincorporated into RNA and DNA respectively. |
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| Fluoruracil Anbieter Lieferant Produzent Hersteller Vertrieb Händler. Global( 371)Lieferanten |
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| 51-21-8(Fluoruracil)Verwandte Suche: |
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Sulfamerazin
5-Fluoruridin
Rotenon
1-β-D-Arabinofuranosyl-5-fluor-(1H,3H)-pyrimidin-2,4-dion
Resmethrin (ISO)
alpha-Cyan-3-phenoxybenzyl-3-(2-chlor-3,3,3-trifluorprop-1-enyl)-2,2-dimethylcyclopropan-carboxylat, 1:1 Gemisch der(Z)-(1R,3R), S-ester und(Z)-(1S,3S), R-ester
5-Fluor-1-(tetrahydro-2-furyl)uracil
5-Fluor-2'-desoxyuridin
5-Fluoruracil-4-carbonsure
2-Chloro-5-fluoropyrimidine
Fluoruracil
pyrimidinedione
5-Methyluracil
Fluor
Flucytosin
5-Fluoropyrimidine
3,5,5-Trimethyl-2-cyclohex-2-enon
6-Methyluracil
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[180]-5-Fluorouracil
2,4(1H,3H)-Pyrimidinedione, 5-fluoro-
2,4-dioxo-5-fluoropyrimidine
3h)-pyrimidinedione,5-fluoro-4(1h
5-faracil
5-Flouracyl
5-fluor-2,4(1h,3h)-pyrimidindion
5-Fluor-2,4-dihydroxypyrimidin
5-Fluor-2,4-pyrimidindiol
5-Fluoracil
5-fluoropyrimidin-2,4-diol
5-fluoro-uraci
5-Fluoruracil
5-Ftouracyl
Adrucil
Arumel
Carzonal
cincofu
Effluderm
Effluderm (free base)
effluderm(freebase)
Efudex
Efudix
Efurix
Fluoroblastin
Fluoroplex
fluoro-uracile
fluoro-uracilo
fluorouracilum
Fluracil
Fluracilum
Fluri
Fluril
fluroblastin
flurouracil
Ftoruracil
Kecimeton
NSC 19893
nsc19893
nsc-19893
phthoruracil
Queroplex
Ro 2-9757
ro2-9757
Timazin
U-8953
Ulup
Uracil, 5-fluoro-
51-21-8
5-FLUOROURACIL
5-FLUOROPYRIMIDINE-2,4(1H,3H)-DIONE
5-Fluoropyrimidine-2,4-dione
5-FU
5-FLUORO-1H-PYRIMIDINE-2,4-DIONE
5-FLUORO-2,4(1H,3H)-PYRIMIDINEDIONE
5-FLUORO-2,4-DIHYDROXYPYRIMIDINE
5-fluoro-2,4-pyrimidinedione
Building Blocks
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