Ethyl acetoacetate

Ethyl acetoacetate Property

mp : −43 °C(lit.) bp : 181 °C(lit.) density : 1.029 g/mL at 20 °C(lit.) vapor density : 4.48 (vs air) vapor pressure : 1 mm Hg ( 28.5 °C) refractive index : n20/D 1.419 FEMA : 2415 Fp : 185 °F solubility : 116 g/L (20°C) Water Solubility : 116 g/L (20 ºC) Merck : 14,3758 BRN : 385838 Stability:: Stable. Incompatible with acids, bases, oxidizing agents, reducing agents, alkali metals. Combustible. CAS DataBase Reference: 141-97-9(CAS DataBase Reference) NIST Chemistry Reference: Butanoic acid, 3-oxo-, ethyl ester(141-97-9) EPA Substance Registry System: Butanoic acid, 3-oxo-, ethyl ester(141-97-9)

Safety

Hazard Codes : Xi Risk Statements : 36 Safety Statements : 26-24/25 RIDADR : UN 1993 WGK Germany : 1 RTECS : AK5250000 HazardClass : 3.2 PackingGroup : III Hazardous Substances Data: 141-97-9(Hazardous Substances Data)

Ethyl acetoacetate Chemical Properties,Usage,Production

Chemical Properties Colourless, clear liquid Usage Ethyl acetoacetate (EAA) is used as starting material for the syntheses of alpha-substituted acetoacetic esters and cyclic compounds, e.g. pyrazole, pyrimidine and coumarin derivatives as well as intermediate for vitamins and pharmaceuticals. Product Data Sheet General Description A colorless liquid with a fruity odor. Flash point 185°F. Boiling point 365°F. May cause adverse health effects if ingested or inhaled. May irritate to skin, eyes and mucous membranes. Used in organic synthesis and in lacquers and paints. Air & Water Reactions Flammable. Reactivity Profile Ethyl acetoacetate, a beta-keto ester, is more reactive than many esters. Undergoes an exothermic cleavage reaction in the presence of concentrated base. Reacts with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Mixing with 2,2,2-tris(bromomethyl)ethanol and zinc led to an explosion [US Patent 3 578 619, Crotonaldehyde may rapidly polymerize with Ethyl acetoacetate (Soriano, D.S. et al. 1988. Journal of Chemical Education 65:637.).1971]. Health Hazard Liquid may cause mild irritation of eyes.

Ethyl acetoacetate Preparation Products And Raw materials

Raw materials Acetyl ketene Etanol Sodium Sodium ethoxide METHANE

Preparation Products 3-CHLORO-4-METHYL-7-HYDROXYCOUNMARIN ETHYL 2-HYDROXY-4-METHYL-5-PYRIMIDINECARBOXYLATE BISPYRAZOLONE 4-CHLORO-2,6-DIMETHYL-NICOTINIC ACID ETHYL 2,4-DIMETHYLQUINOLINE-3-CARBOXYLATE Disperse Yellow H-4GL ETHYL 2-ACETYL-3-OXO-HEXANOATE 1-(6-CHLORO-2-HYDROXY-4-PHENYL-QUINOLIN-3-YL)-ETHANONE Ethyl 3-hydroxybutyrate 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID PHENOXYACETIC ACID 5,7-Dihydroxy-4-methylcoumarin 4-HYDROXY-2-METHYLQUINOLINE ETHYL 4-CHLORO-2,6-DIMETHYLPYRIDINE-3-CARBOXYLATE 7-Acetoxy-4-methylcoumarin 3-ETHOXYCARBONYL-5,6-DIHYDRO-2-METHYL-4H-PYRAN N-Phenylglycine potassium salt TIADINIL ETHYL 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLATE 1-Bromo-5-hexanone Pentoxifylline 6-TERT-BUTYL-4-METHYLCOUMARIN 4-Methylumbelliferone ETHYL 2-(HYDROXYIMINO)-3-OXOBUTANOATE Cloricromene 2,4-DIMETHYLQUINOLINE-3-CARBOXYLIC ACID Acetoacetic Acid Ethyl 3-anilinobut-2-enoate (5-METHYL-1-PHENYL-1H-PYRAZOL-4-YL)METHANOL Chrysin 4,7-DIMETHYLCOUMARIN 3-Ethyl-4-methyl-3-pyrrolin-2-one 4-Chloro-6-methyl-2-(methylthio)pyrimidine 2-Amino-6-methyl-4-pyrimidinol 4-Methylcumarin 1,3-Dimethyl-5-hydroxypyrazole 6-Methyl-2-(methylthio)pyrimidin-4-ol 7,8-DIHYDROXY-4-METHYLCOUMARIN 3-METHYL-5-PHENYL-4-ISOXAZOLECARBOXYLIC ACID ethyl 2-[2-(diethylamino)ethyl]acetoacetate

Ethyl acetoacetate Suppliers      Global( 265)Suppliers      BELGIUM 1 CANADA 1 CHINA 173 Europe 5 GERMANY 10 INDIA 3 JAPAN 7 Slovakia 1 SWITZERLAND 3 UKRAINE 1 UNITED KINGDOM 9 USA 51 Global 265

Supplier Tel Fax Email Country ProdList Advantage Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333 021-50323701 sale@aladdin-e.com CHINA 24330 65 Shanghai Macklin Biochemical Co.,Ltd. 021-51821861 021-51821727 sales@macklin.cn CHINA 9960 55 J & K SCIENTIFIC LTD. -- -- jkinfo@jkchemical.com;market3@jkchemical.com CHINA 96847 76 Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-59487313(Beijing) +86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com CHINA 40407 62 3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037 86-21-50328109 67055399@qq.com CHINA 15983 69 Alfa Aesar 400-610-6006; 021-67582000 021-67582001/03/05 saleschina@alfa-asia.com CHINA 30333 84 TCI (Shanghai) Development Co., Ltd. -- -- info@chemicalbook.com CHINA 22159 81 Beijing dtftchem Technology Co., Ltd. 13651141086; 86(10)60275028、60275820 86 (10) 60270825 dtftchem@sina.com CHINA 4703 62 Energy Chemical 021-58432009 / 400-005-6266 021-58436166-800 info@energy-chemical.com CHINA 44198 61 Beijing Ouhe Technology Co., Ltd +86-10-4006331231;+86-10-51280831;+86-10-82967028 +86-10-82967029 sales@ouhechem.com CHINA 10815 60