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| CAS番号. | 703-95-7 |
| 化学名: | 5-フルオロオロチン酸 |
| 别名: | 5-フルオロオロチン酸;5-フルオロ-2,6-ジオキソ-1,2,3,6-テトラヒドロ-4-ピリミジンカルボン酸;1,2,3,6-テトラヒドロ-2,6-ジオキソ-5-フルオロ-4-ピリミジンカルボン酸;5-フルオロ-1,2,3,6-テトラヒドロ-2,6-ジオキソ-4-ピリミジンカルボン酸;5-フルオロオロト酸;5-フルオロオロット酸;5-フルオロオロチン酸N水和物;フルオロオロチン酸;5-フルオロオロチン酸一水和物 |
| 英語化学名: | 5-Fluoroorotic acid |
| 英語别名: | fo;foa;5-FOA;5' FOA;ro2-9945;nsc31712;ent-26398;Fluoxydin;WR 152520;5-Fluoroorotic |
| CBNumber: | CB6325772 |
| 分子式: | C5H3FN2O4 |
| 分子量: | 174.09 |
| MOL File: | 703-95-7.mol |
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| 5-フルオロオロチン酸 物理性質 |
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| solubility : |
NH4OH 4 M: 50 mg/mL, clear, faintly yellow
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5-フルオロオロチン酸 化学特性,用途語,生産方法 |
化学的特性
White to Off-White Crystalline Solid |
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使用
5-FOA has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in malarial parasites. The combination of 5-FOA and uracil has been effective in treating mice infected with Plasmodium yoelli. 5-FOA may also have potential in the treatment of human malarial infections when used in combination with other agents. |
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| 5-フルオロオロチン酸 上流と下流の製品情報 |
原材料
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準備製品
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| 5-フルオロオロチン酸 生産企業 Global( 159)Suppliers |
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703-95-7
1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylicaci
1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylicacid
5-fluoro-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylicaci
5-fluoroorotate
5-fluoro-oroticaci
ent-26398
fluorooroticacid
fo
foa
nsc31712
ro2-9945
2,6-Dihydroxy-5-fluoropyrimidine-4-carboxylic acid
5-FLUOROURACIL-4-CARBOXYLIC ACID
5' FOA
5-FOA
5-FLUOROOROTIC ACID
5-FLUORO-2,6-DIOXO-3H-PYRIMIDINE-4-CARBOXYLIC ACID
RARECHEM AH BS 0043
5-FLUOROORTIC ACID
5-Fluoroorotic
Fluoxydin
Fluoroorotic-Acid (5' FOA)
5-fluorouracil-6-carboxylic acid
5-Fluoroorotic acid monohydrate 98%
5-Fluorooroticacidmonohydrate98%
5-FLUOROOROTIC ACID HYDRATE 99%
4-PYRIMIDINECARBOXYLICACID,5-FLUORO-1,2,3,6-TETRAHYDRO-2,6-DIOXO
4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-
WR 152520
5-Fluoro-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid
5-フルオロオロチン酸
5-フルオロ-2,6-ジオキソ-1,2,3,6-テトラヒドロ-4-ピリミジンカルボン酸
1,2,3,6-テトラヒドロ-2,6-ジオキソ-5-フルオロ-4-ピリミジンカルボン酸
5-フルオロ-1,2,3,6-テトラヒドロ-2,6-ジオキソ-4-ピリミジンカルボン酸
5-フルオロオロト酸
5-フルオロオロット酸
5-フルオロオロチン酸N水和物
フルオロオロチン酸
5-フルオロオロチン酸一水和物
ヌクレオシド，ヌクレオチド＆関連試薬
フッ素化剤，含フッ素ビルディングブロック＆含フッ素生理活性化合物
ヘテロ環化合物 (含フッ素合成ブロック)
含フッ素合成ブロック
核酸塩基と類似体
生化学
有機合成化学
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