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Indometacin

Indometacin Suppliers list
Company Name:BEST-REAGENT  Gold
Tel:028-85973071 028-85973075
Email:service@best-reagent.com
Products Intro: Product Name:IndoMethacin
CAS:53-86-1
Purity:99% Package:5g,25g,100,500g,1Kg
Company Name:Wuhan Hezhong Bio-chemical Manufacture co ltd  Gold
Tel:021-68580270 / 18121115343
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Products Intro: Product Name:Indometacin
CAS:53-86-1
Purity:99% HPLC Package:100G;500G;1KG;25KG
Company Name:WuHan YuanCheng Gongchuang Technology Co.Ltd  Gold
Tel:027-50756129/250/126/076
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Products Intro: Product Name:Indometacin
CAS:53-86-1
Purity:99% Package:25kg/carton
Company Name:J & K SCIENTIFIC LTD.  
Tel:400-666-7788 +86-10-82848833
Email:jkinfo@jkchemical.com;market3@jkchemical.com
Products Intro: Product Name:IndoMethacin
CAS:53-86-1
Purity:98.0%(LC&T) Package:25G,500G
Company Name:Meryer (Shanghai) Chemical Technology Co., Ltd.  
Tel:+86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-59487313(Beijing)
Email:sh@meryer.com
Products Intro: Product Name:IndoMethacin
CAS:53-86-1
Purity:>98.0%(LC)(T) Package:25g;500g Remarks:I0655
Indometacin Basic information
Product Name:Indometacin
Synonyms:AURORA KA-6542;INDOCIN;INDOMETACIN;INDOMETACINE;INDOMETHACIN;INDOMETHACINE;LABOTEST-BB LT00244830;1-(P-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
CAS:53-86-1
MF:C19H16ClNO4
MW:357.79
EINECS:200-186-5
Product Categories:PHARMACEUTICALS;Active Pharmaceutical Ingredients;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Lipid signaling;INDOCIN;Other APIs;Pharmaceutical raw chemicals
Mol File:53-86-1.mol
Indometacin Structure
Indometacin Chemical Properties
mp 155-162 °C
storage temp. Store at RT
solubility ethanol: 50 mg/mL, clear, yellow-green
Merck 4968
Stability:Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference53-86-1(CAS DataBase Reference)
NIST Chemistry ReferenceIndomethacin(53-86-1)
EPA Substance Registry System1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-(53-86-1)
Safety Information
Hazard Codes T+,Xi,T
Risk Statements 28-36/37/38-39/23/24/25-23/24/25
Safety Statements 28-36/37-45-36-26
RIDADR UN 2811 6.1/PG 1
WGK Germany 3
RTECS NL3500000
F 8-10
HazardClass 6.1
PackingGroup I
Hazardous Substances Data53-86-1(Hazardous Substances Data)
MSDS Information
Indometacin Usage And Synthesis
Chemical PropertiesCrystalline Solid
UsageInhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD
Usageantiinflammatory, antipyretic, analgesic
General DescriptionCrystals.
Air & Water ReactionsPractically insoluble in water. Decomposes in alkali.
Reactivity ProfileA weak organic acid.
Fire HazardNon-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Biological ActivityCyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC 50 values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent.
Indometacin Preparation Products And Raw materials
Preparation ProductsAcemetacin-->indomethacin farnesil
Raw materialsp-Anisidine-->Levulinic acid-->4-Chlorobenzoyl chloride
Tag:Indometacin(53-86-1) Related Product Information
Diclofenac potassium Talmetacin AURORA KA-4884 INDOMETHACIN SODIUM TROPESIN 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, 2-(2 -((4-(benzoylamino)-5-(dipropylamino)-1,5-dioxopentyl)oxy)ethoxy)-2-ox oethyl ester, (+-)- (4-Fluorophenyl)methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol e-3-acetate 2-carboxyphenyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetate PROGLUMETACIN MALEATE 2-((2-carboxyphenoxy)carbonyl)phenyl-1-(4-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetate Acemetacin Indometacin 4-Chlorophenylacetic acid Methoxyacetic acid Indole Methyl acrylate 4-Methoxyphenylacetic acid ACETIC ACID