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Doxorubicin hydrochloride

CAS No.25316-40-9
Chemical Name:Doxorubicin hydrochloride
Synonyms:DOX;ADR;Caely;CAELYX;fi6804;FI 106;DOX HCl;Lipodox;ADRIACIN;Ardriamycin
CBNumber:CB0110633
Molecular Formula:C27H30ClNO11
Formula Weight:579.98
MOL File:25316-40-9.mol
Doxorubicin hydrochloride Property
mp : 216 °C (dec.)(lit.)
storage temp. : 2-8°C
solubility : H2O: 10 mg/mL, clear, red-orange
Merck : 13,3473
CAS DataBase Reference: 25316-40-9(CAS DataBase Reference)
EPA Substance Registry System: 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-. alpha.-L-lyxo-hexopyranosyl) oxy]-7,8,9,10-tetrahydro- 6,8,11-trihydroxy-8-(hydroxyacetyl)- 1-methoxy-, hydrochloride, (8S,10S)-(25316-40-9)
Safety
Hazard Codes : T,T+,Xi
Risk Statements : 45-22-40-26/27/28-36/38
Safety Statements : 53-45-36/37/39-22-7/9
WGK Germany : 3
RTECS : QI9295900
F : 10-21

Doxorubicin hydrochloride Chemical Properties,Usage,Production

Chemical Properties
Orange-Red Crystalline Solid
Usage
Used as an antineoplastic
Usage
Strong fluorescent dye intercalating into DNA. Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA. Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent.
Usage
Antibacterial;DNA intercalant
Usage
Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumour agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently.
Usage
Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumor agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently.
General Description
Orange-red thin needles. Aqueous solutions yellow-orange at acid pHs, orange-red at neutral pHs, and violet blue over pH 9.
Air & Water Reactions
Water soluble.
Reactivity Profile
Amines, like Doxorubicin hydrochloride, are weak chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Fire Hazard
Doxorubicin hydrochloride is probably combustible.
Biological Activity
Antitumor antibiotic agent that inhibits DNA topoisomerase II. DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis.
Doxorubicin hydrochloride Preparation Products And Raw materials
Raw materials
Daunorubicin
Preparation Products
Pirarubicin
Doxorubicin hydrochloride Suppliers      Global( 247)Suppliers     
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Dalian Meilun Biotech Co., Ltd. 0411-66771943；0411-667719420411-66771945sales@meilune.comCHINA 5010 58
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Shanghai Hanjing Chemicals Co., Ltd. +86 (21) 3700-9251 / 3700-9252+86 (21) 3700-9253sales@hanjinggroup.com, zongjf@sina.comCHINA 24 55
Shanghai Boyle Chemical Co., Ltd. Mr Qiu 86-21-50182298(Domestic Market)Miss Xu 86-21-50180596(Abroad Market)86-21-57758967sales@boylechem.comCHINA 5604 55
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INTATRADE GmbH +49 3493/605464+49 3493/605470sales@intatrade.deGERMANY 3590 66
 
25316-40-9(Doxorubicin hydrochloride)Related Search:
Tetrahydro-4H-pyran-4-one Cetirizine hydrochloride Betaine Centchroman Tramadol hydrochloride ETHYLENEDIAMINE TETRAKIS(PROPOXYLATE-BLOCK-ETHOXYLATE) TETROL Doxorubicin hydrochloride Vitamin E Diphenhydramine Hydrochloride Topotecan hydrochloride Adriamycin AMINO ACIDS Daunorubicin Glycine ALTRENOGEST Sibutramine hydrochloride 5-Chlorovaleric acid Pralmorelin
ADRIACIN ADRIBLASTINA ADRIBLASTINA HYDROCHLORIDE ADRIAMYCIN HCL ADRIAMYCIN HYDROCHLORIDE (8s-cis)-10-[(3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride 25316-40-9 14-HYDROXYDAUNOMYCIN HCL 14-HYDROXYDAUNOMYCIN HYDROCHLORIDE BioChemical Antibiotics A to Z Antibiotics A-F Antibiotics CAELYX DOX HYDROCHLORIDE DOXORUBICIN HCL DOXORUBICIN HYDROCHLORIDE HYDROXYDAUNORUBICIN HYDROCHLORIDE (8s-cis)-hlorid 10-((3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-12-naphthacenedione 8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-xy)-hydroc admhydrochloride Ardriamycin fi6804 DOX DOXORUBICIN HYDROCHLORIDE, FOR FLUORESCE NCE DOXORUBICIN HYDROCHLORIDE WITH EXTENDER AND PRESERVA DOXORUBICIN HYDROCHLORIDE (ADRIAMYCIN HC L) \ APOPTOSIS INDUCER DOXORUBICIN HYDROCHLORIDE SOLUTION 2 MG/ DOXORUBICIN HYDROCHLORIDE 98+% DOXORUBICIN HCL/ DOXORUBICIN HYDROCHLORIDE DoxorubicinHcl,Usp28 C27H30ClNO11 (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-a-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione Caely Adriamycin HCl Solution 5,12-Naphthacenedione, 10-(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)- DOXORUBICINHCL(FDA) 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- ADR Adriamycin, hydrochloride (8CI) Adriblastina RD DOX HCl FI 106 Lipodox Doxorubicin HCl(BICINS) C27H29NO11ClH Doxorubicin Hydrochloride /Adriamycin hydrochloride APIs Active Pharmaceutical Ingredients (8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride C27H29O11NHCl API (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione 14-hydroxyribomycin Intermediates & Fine Chemicals Pharmaceuticals
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