Thalidomide

Company Name:	Shanghai TaoSu Biochemical Technology Co., Ltd. Gold
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Products Intro:	Product Name:Thalidomide CAS:50-35-1 Purity:98% Package:2mg/298RMB

Company Name:	Amoi Yinghua biotechnology Co. Ltd. Gold
Tel:	18605020825
Email:	amoiyh@126.com
Products Intro:	Product Name:Thalidomide CAS:50-35-1 Purity:99% HPLC Package:100g;500g;1kg;5kg

Company Name:	J & K SCIENTIFIC LTD.
Tel:	400-666-7788 +86-10-82848833
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Products Intro:	Product Name:ThalidoMide CAS:50-35-1 Purity:98% Package:500Mg,5g

Company Name:	3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:	86-21-50328103 * 801、802、803、804 Mobile:18930552037
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Products Intro:	Product Name:ThalidoMide;N-(2,6-dioxo-3-piperidinyl)phthaliMide CAS:50-35-1 Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g

Company Name:	Chembest Research Laboratories Limited
Tel:	+86(0)21-20908456
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Products Intro:	Product Name:ThalidoMide CAS:50-35-1 Remarks:C14251

Thalidomide Basic information

Product Name:	Thalidomide
Synonyms:	(+/-)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3(2H)-DIONE;2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISO-INDOLE-1,3(2H)-DIONE;ALPHA-PHTHALIMIDOGLUTARIMIDE;3-PHTHALIMIDOGLUTARIMIDE;(+/-)-THALIDOMIDE;THALIDOMIDE;(+/-)-N-(2,6-DIOXO-3-PIPERIDINYL)PHTHALIMIDE;N-(2,6-DIOXO-3-PIPERIDINYL)PHTHALIMIDE
CAS:	50-35-1
MF:	C13H10N2O4
MW:	258.23
EINECS:	200-031-1
Product Categories:	Intermediates & Fine Chemicals;Pharmaceuticals;API's;Cytokine signaling;Signalling;Influenza Viruses;Angiogenesis and Metastasis;Inhibitor;ROCCAL
Mol File:	50-35-1.mol

Thalidomide Chemical Properties

mp	269-271°C
storage temp.	Store at RT
solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.6 mg/mL
Water Solubility	<0.1 g/100 mL at 22 ºC
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference	50-35-1(CAS DataBase Reference)
NIST Chemistry Reference	Phthalimide, n-(2,6-dioxo-3-piperidyl)-(50-35-1)
EPA Substance Registry System	1H-Isoindole-1,3( 2H)-dione, 2-(2,6-dioxo-3-piperidinyl)- (50-35-1)

Safety Information

MSDS Information

Provider	Language
2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione	English
SigmaAldrich	English

Thalidomide Usage And Synthesis

Chemical Properties	White Powder
Usage	antiinfective (topical)
Usage	Inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative. There is now a growing clinical interest in Thalidomide, and it is introduced as an immunomodulatory agent used primarily in combination with dexamethasone to treat multiple myeloma.
General Description	Needles or white powder.
Air & Water Reactions	Insoluble in water.
Reactivity Profile	Organic amides/imides, such as Thalidomide, react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Fire Hazard	Flash point data for Thalidomide are not available; however, Thalidomide is probably combustible.
Biological Activity	Teratogen, sedative-hypnotic with inherent anti-inflammatory properties. A selective inhibitor of tumor necrosis factor α (TNF- α ) synthesis.

Thalidomide Preparation Products And Raw materials

Tag:Thalidomide(50-35-1) Related Product Information

2-[2,6-DIOXO-3-(TRIFLUOROMETHYL)PIPERIDIN-3-YL]-1H-ISOINDOLE-1,3(2H)-DIONE (R)-(+)-THALIDOMIDE Thalidomide 4,4-Piperidinediol hydrochloride N-Hydroxyphthalimide Bismaleimide N-Methylphthalimide O-Phthalimide DIALIFOS 3-Nitrophthalimide Polyamideimide 4-Aminophthalimide Phthalhydrazide DROPERIDOL Succinimide 2,2,6,6-Tetramethyl-4-piperidinol Diphenoxylate 4-Nitrophthalimide