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| CAS No. | 53-86-1 |
| Chemical Name: | Indometacin |
| Synonyms: | Amuno;Vonum;Catlep;Inacid;Lausit;Tannex;INDOCIN;Bonidin;Dolovin;Indacin |
| CBNumber: | CB1750267 |
| Molecular Formula: | C19H16ClNO4 |
| Formula Weight: | 357.79 |
| MOL File: | 53-86-1.mol |
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| Indometacin Property |
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| storage temp. : |
Store at RT |
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| solubility : |
ethanol: 50 mg/mL, clear, yellow-green
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| Stability:: |
Stable. Incompatible with strong oxidizing agents. |
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Indometacin Chemical Properties,Usage,Production |
Chemical Properties
Crystalline Solid |
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Usage
Inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD |
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Usage
antiinflammatory, antipyretic, analgesic |
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General Description
Crystals. |
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Air & Water Reactions
Practically insoluble in water. Decomposes in alkali. |
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Reactivity Profile
A weak organic acid. |
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Fire Hazard
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. |
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Biological Activity
Cyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC 50 values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent. |
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| Indometacin Suppliers Global( 201)Suppliers |
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