(+)-Griseofulvin

CAS No.	126-07-8
Chemical Name:	(+)-Griseofulvin
Synonyms:	Fulcin;Gricin;Griseo;Grysio;Poncyl;Amudane;Fulcine;Fulvina;Greosin;Lamoryl
CBNumber:	CB1766075
Molecular Formula:	C17H17ClO6
Formula Weight:	352.77
MOL File:	126-07-8.mol

(+)-Griseofulvin Property

mp :	218-220 °C(lit.)

alpha :

354 º (c=1, dimethylform)

storage temp. :

−20°C

Water Solubility :

practically insoluble

Merck :

14,4549

BRN :

95226

CAS DataBase Reference:

126-07-8(CAS DataBase Reference)

NIST Chemistry Reference:

Griseofulvin(126-07-8)

EPA Substance Registry System:

Spiro[benzofuran- 2(3H),1'-[2]cyclohexene]- 3,4'-dione, 7-chloro-2',4,6-trimethoxy- 6'-methyl-, (1'S,6'R)-(126-07-8)

Safety

Hazard Codes :

T,Xn

Risk Statements :

60-61-40-43-45

Safety Statements :

53-22-36/37/39-45

WGK Germany :

RTECS :

WG9800000

Hazardous Substances Data:

126-07-8(Hazardous Substances Data)

(+)-Griseofulvin Chemical Properties,Usage,Production

Chemical Properties
Crystalline Solid

Usage
adrenegic blocker, Ca channel blocker, coronary vasodilator, antiarrhythmic

Usage
antifungal, inhibits mitosis in metaphase

Usage
Griseofulvin is a spirobenzofuran produced by a number of Penicillium species, first isolated in the 1930s by Raistrick's group. Griseofulvin is a selective antifungal agent used to treat skin infections in animals and humans. Griseofulvin acts by binding to fungal tubulin and inhibiting the mitotic spindle. Griseofulvin's ability to bind to keratin is considered an important aspect of the metabolite's access to dermatophytic fungi. More recently, griseofulvin has become an important phenotypic marker in Penicillium taxonomy.

Usage
It is an antifungal drug. It is used both in animal and in humans, to treat rigworm infections of the skin and nails. It is derived from the mold Penicillium griseofulvum

General Description
White to pale cream-colored crystalline powder. Odorless or almost odorless. Tasteless. Sublimes without decomposition at 410°F.

Air & Water Reactions
Insoluble in water.

Reactivity Profile
(+)-Griseofulvin is incompatible with strong oxidizing agents. .

Fire Hazard
Flash point data for (+)-Griseofulvin are not available. (+)-Griseofulvin is probably combustible.

(+)-Griseofulvin Preparation Products And Raw materials

Raw materials
Oxalic acid Starch

Preparation Products

(+)-Griseofulvin Suppliers Global( 159)Suppliers

Supplier	Tel	Fax	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	--	--	jkinfo@jkchemical.com;market3@jkchemical.com	CHINA	96847	76
3B Pharmachem (Wuhan) International Co.,Ltd.	86-21-50328103 * 801、802、803、804 Mobile:18930552037	86-21-50328109	67055399@qq.com	CHINA	15983	69
Alfa Aesar	400-610-6006; 021-67582000	021-67582001/03/05	saleschina@alfa-asia.com	CHINA	30333	84
TAIYUAN RHF CO.,LTD.	+86 351 7031519	+86 351 7031519	sales@RHFChem.com	CHINA	2366	56
TCI (Shanghai) Development Co., Ltd.	--	--	info@chemicalbook.com	CHINA	22159	81
Energy Chemical	021-58432009 / 400-005-6266	021-58436166-800	info@energy-chemical.com	CHINA	44198	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18	0086-571-85864795	sales@capotchem.com	CHINA	18282	66
Beijing Ouhe Technology Co., Ltd	+86-10-4006331231;+86-10-51280831;+86-10-82967028	+86-10-82967029	sales@ouhechem.com	CHINA	10815	60
Chemfun Medical Technology(Shanghai) Co., Ltd.	021-67220633 & 021-37212706	+86-21-67220638	chemfun@chemfun.net	CHINA	21915	59
Nanjing Chemlin Chemical Co., Ltd	025-83697070; 010-68547217	+86-25-83453306	sales@chemlin.com.cn	CHINA	20120	64

126-07-8((+)-Griseofulvin)Related Search:

5-CHLORO-2-METHOXYBENZALDEHYDE 1-(3-CHLORO-4-HYDROXYPHENYL)-1-ETHANONE 4'-hydroxy-2-methylpropiophenone 1-(5-CHLORO-2,4-DIMETHOXY-PHENYL)-ETHANONE 4-HYDROXY-2,2-DIMETHYL-BENZOFURAN-3-ONE 3-(3-CHLORO-PHENYL)-PROPAN-1-OL 3'-Chloropropiophenone 3-CHLOROPHENETHYLALCOHOL 1-METHOXYCYCLOHEXENE 2-CHLORO-3-METHOXYPHENOL 1-(4-METHOXYPHENYL)-3-METHYLBUTAN-1-ONE 5-CHLORO-2-METHOXYACETOPHENONE ALLYL 2-CHLOROPHENYL ETHER (+)-Griseofulvin TRANSFAT Difluorochloromethane trans,trans-2,4-Undecadienal Cyclohexene

(+)-GRISEOFULVIN GRISEOFULVIN [2S-TRANS]-7-CHLORO-2,4,6-TRIMETHOXY-6'-METHYLSPIRO[BENZOFURAN-2(3H), 1'(2)-CYCLOHEXANE]-3,4'-DIONE (2S)-TRANS-7-CHLORO-2',4,6-TRIMETHOXY-6'-METHYLSPIRO(BENZOFURAN-2[3H],1'-[2]CYCLOHEXENE)-3,4'-DIONE Antibiotics G-M Antibiotics Antibiotics A to Z BioChemical 126-07-8 7-CHLORO-2',4,6-TRIMETHOXY-6'-METHYL-, (1'S-TRANS)-SPIRO(BENZOFURAN-2(3H),1'-(2)CYCLOHEXENE)-3,4'-DIONE (+)-griseofulvi (2s-trans)-7-chloro-2’,4,6-trimethoxy-6’-methylspiro[benzofuran-2(3h),1’-[2]cy (2s-trans)-xy-6’-methyl 2’-en-4’-one) -6’-beta-methyl- 6-dimethoxycoumaran-3-one-2-spiro-1’-(2’-methoxy-6’-methylcyclohex-7-chloro- 7-Chloro-2',4,6-trimethoxy-6'beta-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione 7-chloro-4,6,2’-trimethoxy-6’-methylgris-2’-en-3,4’-dione 7-Chloro-4,6,2'-trimethoxy-6'-methylgris-2'-en-3,4'-dione Amudane Biogrisin-fp clohexene]-3,4’-dione Curling factor curlingfactor Delmofulvina Fulcin Fulcine Fulvican grisactin fulvicangrisactin Fulvicin Fulvicin-P/G Fulvicin-U/F Fulvina Fulvinil Fulvistatin Fungivin Greosin Gresfeed Gricin Grifulin Grifulvin Grifulvin V grifulvinv Grisactin Griscofulvin Grisefuline Griseo Griseofulvin-forte Griseofulvinum Grisetin Grisofulvin Grisovin Grisovin FP grisovinfp Gris-peg Grizeofulvin Grysio Guservin